Quantum Methods for Neural Networks and Application to Medical Image Classification

Jonas Landman1,2, Natansh Mathur1,3, Yun Yvonna Li4, Martin Strahm4, Skander Kazdaghli1, Anupam Prakash1, and Iordanis Kerenidis1,2

1QC Ware, Palo Alto, USA and Paris, France
2IRIF, CNRS - University of Paris, France
3Indian Institute of Technology Roorkee, India
4F. Hoffmann La Roche AG

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Abstract

Quantum machine learning techniques have been proposed as a way to potentially enhance performance in machine learning applications.
In this paper, we introduce two new quantum methods for neural networks. The first one is a quantum orthogonal neural network, which is based on a quantum pyramidal circuit as the building block for implementing orthogonal matrix multiplication. We provide an efficient way for training such orthogonal neural networks; novel algorithms are detailed for both classical and quantum hardware, where both are proven to scale asymptotically better than previously known training algorithms.
The second method is quantum-assisted neural networks, where a quantum computer is used to perform inner product estimation for inference and training of classical neural networks.
We then present extensive experiments applied to medical image classification tasks using current state of the art quantum hardware, where we compare different quantum methods with classical ones, on both real quantum hardware and simulators. Our results show that quantum and classical neural networks generates similar level of accuracy, supporting the promise that quantum methods can be useful in solving visual tasks, given the advent of better quantum hardware.

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[61] Yumin Dong, Xuanxuan Che, Yanying Fu, Hengrui Liu, Yang Zhang, and Yong Tu, "Classification of knee osteoarthritis based on quantum-to-classical transfer learning", Frontiers in Physics 11, 1212373 (2023).

[62] Jingwei Wen, Zhiguo Huang, Dunbo Cai, and Ling Qian, "Enhancing the expressivity of quantum neural networks with residual connections", Communications Physics 7 1, 220 (2024).

[63] Randall Correll, Sean J. Weinberg, Fabio Sanches, Takanori Ide, and Takafumi Suzuki, "Quantum Neural Networks for a Supply Chain Logistics Application", Advanced Quantum Technologies 6 7, 2200183 (2023).

[64] Josh Green and Jingbo Wang, "Quantum encoding of functions and images with matrix product states", Physical Review A 113 5, 052616 (2026).

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[68] Gurinder Singh, Hongni Jin, and Kenneth M. Merz, "Benchmarking MedMNIST dataset on real quantum hardware", Scientific Reports 16 1, 9017 (2026).

[69] Xiang Rao, Chenjie Luo, Xupeng He, and Kwak Hyung, ADIPEC (2024).

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[77] Hongjie Liu, Tengfei Yuan, Xinhuan Zhang, and Hongzhe Xu, "Quantum entanglement and self-attention neural networks: An investigation into passengers and stops characteristics for optimal bus stop localization", Information Fusion 112, 102527 (2024).

[78] Daniele Lizzio Bosco, Shuteng Wang, Giuseppe Serra, and Vladislav Golyanik, "QNeRF: Neural Radiance Fields on a Simulated Gate-Based Quantum Computer", arXiv:2601.05250, (2026).

[79] Snehal Raj and Brian Coyle, "QuIC: Quantum-Inspired Compound Adapters for Parameter Efficient Fine-Tuning", arXiv:2502.06916, (2025).

[80] Léo. Monbroussou, Beatrice Polacchi, Verena Yacoub, Eugenio Caruccio, Giovanni Rodari, Francesco Hoch, Gonzalo Carvacho, Nicolò Spagnolo, Taira Giordani, Mattia Bossi, Abhiram Rajan, Niki Di Giano, Riccardo Albiero, Francesco Ceccarelli, Roberto Osellame, Elham Kashefi, and Fabio Sciarrino, "Photonic quantum convolutional neural networks with adaptive state injection", Advanced Photonics 7, 066012 (2025).

[81] Laia Domingo, "Classical and quantum reservoir computing: development and applications in machine learning", arXiv:2310.07455, (2023).

[82] Riddhi S. Gupta, Carolyn E. Wood, Teyl Engstrom, Jason D. Pole, and Sally Shrapnel, "Quantum Machine Learning for Digital Health? A Systematic Review", arXiv:2410.02446, (2024).

[83] Sohum Thakkar, Skander Kazdaghli, Natansh Mathur, Iordanis Kerenidis, André J. Ferreira-Martins, and Samurai Brito, "Improved Financial Forecasting via Quantum Machine Learning", arXiv:2306.12965, (2023).

[84] Mehri Mehrnia and Mohammed S. M. Elbaz, "Stochastic Entanglement Configuration for Constructive Entanglement Topologies in Quantum Machine Learning with Application to Cardiac MRI", arXiv:2507.11401, (2025).

[85] Paolo Marcandelli, Stefano Mariani, Martina Siena, and Stefano Markidis, "A Continuous-Variable Quantum Fourier Layer: Applications to Filtering and PDE Solving", arXiv:2603.17847, (2026).

[86] Iordanis Kerenidis and El-Amine Cherrat, "Quantum Agents for Algorithmic Discovery", arXiv:2510.08159, (2025).

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